Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?
نویسندگان
چکیده
منابع مشابه
A population-based algorithm for the railroad blocking problem
Railroad blocking problem (RBP) is one of the problems that need an important decision in freight railroads. The objective of solving this problem is to minimize the costs of delivering all commodities by deciding which inter-terminal blocks to build and by specifying the assignment of commodities to these blocks, while observing limits on the number and cumulative volume of the blocks assemble...
متن کاملBlocking the Deadly Effects of the NMDA Receptor in Stroke
Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain.
متن کاملThe Mechanism of the Effect of Calcium-blocking Drugs on the Treatment of Angina
Dans cet article Jes auteurs ont rappele les bases physiopathologiques et mecanisme d'action des antagonistes de (Ca + ) dans le traitement de l'angine de poitrine.
متن کاملThe effect of blocking of dorsal and lateral paragigantocellularis muscarinic receptors on pain scores in rats
Previous studies have shown that paragigantocellularis nucleus (PGI) neurons contain some neurotransmitters such as GABA, neuropeptides, monoamines, substance P, enkephalin and serotonin. It has been suggested that PGI is a main cholinergic source in the rat’s brain stem. There are few evidences on the presence and importance of cholinergic receptors on PGI neurons with regard to nociception. I...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2017
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-17-2823